Preheat oven to 350°F (177°C).
Cook elbow macaroni in salted boiling water according to package instructions until al dente. Drain and set aside.
In a large saucepan, melt butter over medium heat.
Whisk in flour and cook for 1-2 minutes, stirring constantly to form a roux.
Slowly whisk in whole milk, continue to whisk until the sauce thickens, about 5-7 minutes.
Remove from heat and stir in mature white cheddar and sharp orange cheddar until fully melted and smooth.
Add salt, chili powder, and garlic powder to the cheese sauce, mix well.
Combine cooked macaroni with cheese sauce, stirring gently to coat evenly.
Transfer mac and cheese to a greased baking dish.
For cheese and chili topping: mix grated sharp cheddar cheese with chipotle chili powder and sprinkle evenly over mac and cheese.
For crispy topping: combine Panko breadcrumbs with melted butter and grated sharp cheddar cheese, sprinkle evenly over cheese layer.
Bake uncovered for 25-30 minutes or until the top is golden and bubbly.
Remove from oven and let cool for 5 minutes before serving.